abstract：:Estrogen-related receptor alpha (ERRα), one of orphan nuclear receptors, has been recently revealed as an oncogenic regulator in a variety of cancers. However, the linking gain of ERRα expression and cancer progression in cutaneous squamous cell carcinoma (cSCC) is largely unknown. Here, we showed that the mRNA and pr...

journal_title：European journal of pharmacology

authors： Chen H,Pan J,Zhang L,Chen L,Qi H,Zhong M,Shi X,Du J,Li Q

更新日期：2018-04-15 00:00:00

abstract：:We have investigated the cardiac and pressor responses to (±)-ephedrine and (-)-ephedrine in pentobarbitone anaesthetized male wistar rats. The tachycardiac responses to (±)- and (-)-ephedrine were similar, but pressor responses to (-)-ephedrine (10 mg/kg) were significantly greater than those to (±)-ephedrine, and fo...

journal_title：European journal of pharmacology

authors： Alsufyani HA,Docherty JR

更新日期：2018-04-15 00:00:00

abstract：:Imatinib (IMA) is the standard treatment for CML; however, stopping IMA sometimes results in disease relapse, which suggests that leukemic stem cells (LSCs) remain in such patients, even after complete molecular remission has been achieved. Therefore, new strategies will be required to eradicate LSCs. The Janus kinase...

journal_title：European journal of pharmacology

authors： Yagi K,Shimada A,Sendo T

更新日期：2018-04-15 00:00:00

abstract：:NO plays a key role in the pathological mechanisms of articular diseases. As cytoskeletal proteins are responsible for the polymerization, stabilization, and dynamics of the cytoskeleton network, we investigated whether cytoskeletal proteins are the intracellular pathological targets of NO. We aimed at clarifying whet...

journal_title：European journal of pharmacology

authors： Kao XB,Chen Q,Gao Y,Fan P,Chen JH,Wang ZL,Wang YQ,Chen YN,Yan YP

更新日期：2018-04-05 00:00:00

abstract：:Cirrhosis is often associated with portal hypertension and portal-systemic collateral vessels formation attributed to angiogenesis, which leads to severe complications as hepatic encephalopathy. Sirolimus has anti-fibrosis and anti-angiogenesis effects, but whether it influences the severity of portal-systemic collate...

journal_title：European journal of pharmacology

authors： Wu KC,Huang HC,Chang T,Lee WS,Chuang CL,Hsin IF,Hsu SJ,Lee FY,Chang CC,Lee SD

更新日期：2018-04-05 00:00:00

abstract：:AMN082 is a selective metabotropic glutamate mGlu7 receptor agonist reported to exhibit antidepressant activity. Considering that excessive glutamate release is involved in the pathogenesis of depression, the effect of N,N'-dibenzyhydryl-ethane-1,2-diamine dihydrochloride (AMN082) on glutamate release in rat cerebroco...

journal_title：European journal of pharmacology

authors： Wang CC,Kuo JR,Huang SK,Wang SJ

更新日期：2018-03-15 00:00:00

abstract：:Neuropathic pain is among the most common and difficult-to-treat types of chronic pain and is associated with sodium channel malfunction. The sodium channel blocker ralfinamide has exhibited potent analgesic effects in several preclinical pain models and in patients with mixed neuropathic pain syndromes (Phase II tria...

journal_title：European journal of pharmacology

authors： Liang X,Yu G,Su R

更新日期：2018-03-15 00:00:00

abstract：:Prostate cancer is one of the most severe malignancies in men, and many genes and non-coding RNAs, included microRNAs (miRs), have been demonstrated to regulate prostate cancer progression. In the present study, we investigated the role of miR-671 in prostate cancer cell proliferation. We found that miR-671 was signif...

journal_title：European journal of pharmacology

authors： Yu Y,Wang Z,Sun D,Zhou X,Wei X,Hou W,Ding Y,Ma Y,Hou Y

更新日期：2018-03-15 00:00:00

abstract：:Glucose is the primary energy fuel of life. A glucose transporter, the sodium-glucose transporter (SGLT), is receiving attention as a novel therapeutic target in disease. This review summarizes the physiological role of SGLT in cerebral ischemia, cancer, cardiac disease, and intestinal ischemia, which has encouraged a...

journal_title：European journal of pharmacology

authors： Yamazaki Y,Harada S,Tokuyama S

更新日期：2018-03-05 00:00:00

abstract：:Extracellular diadenosine polyphosphates (ApnA) are recently considered as an endogenous signaling compounds with transmitter-like activity which present in numerous tissues, including heart. It has been demonstrated previously that extracellular ApnA cause alteration of the heart functioning via purine receptors in d...

journal_title：European journal of pharmacology

authors： Pakhomov N,Pustovit K,Potekhina V,Filatova T,Kuzmin V,Abramochkin D

更新日期：2018-02-05 00:00:00

abstract：:Nonalcoholic steatohepatitis (NASH) is one of the most common liver diseases involving chronic accumulation of fat and inflammation, often leading to advanced fibrosis, cirrhosis and carcinoma. However, the pathological mechanism for this is unknown. GPR120/FFAR4 has been recognized as a functional fatty acid receptor...

journal_title：European journal of pharmacology

authors： Nakamoto K,Shimada K,Harada S,Morimoto Y,Hirasawa A,Tokuyama S

更新日期：2018-02-05 00:00:00

abstract：:Although an inhibition of action potential conduction in nerve fibers possibly contributes to at least a part of antinociception produced by analgesics and the adjuvants, it has not been fully examined yet how the conduction inhibition differs in extent among their drugs. We investigated the effects of various antidep...

journal_title：European journal of pharmacology

authors： Hirao R,Fujita T,Sakai A,Kumamoto E

更新日期：2018-01-15 00:00:00

abstract：:The suitability of various neurokinin-2 (NK2) receptor agonists and routes of administration to elicit on-demand voiding of the bladder and bowel, as future therapy for individuals with spinal cord injury, was examined using a rat model. The current study examined the feasibility of alternative routes of administratio...

journal_title：European journal of pharmacology

authors： Marson L,Thor KB,Katofiasc M,Burgard EC,Rupniak NMJ

更新日期：2018-01-15 00:00:00

abstract：:Salidroside, an active constituent from the root of Rhodiola rosea L., has multiple pharmacological effects, such as anti-cancer, anti-inflammatory and anti-oxidative properties, etc. However, its protective effect on bone tissue via regulating calcium homeostasis is yet to be determined. This study was performed to i...

journal_title：European journal of pharmacology

authors： Chen XF,Li XL,Yang M,Song Y,Zhang Y

更新日期：2018-01-15 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive loss of memory and cognitive deficit. The observed amnesia in the early stages of AD is suggested to be a retrieval problem, rather than encoding and consolidation deficit. According to the cholinergic hypothesis of AD, scopolamine i...

journal_title：European journal of pharmacology

authors： Moosavi M,SoukhakLari R,Moezi L,Pirsalami F

更新日期：2018-01-15 00:00:00

abstract：:Beta-lactoglobulin (BLG)-derived peptides may facilitate oral tolerance to whey and prevent cow's milk allergy (CMA). Loading of BLG-peptides in poly(lactic-co-glycolic acid) (PLGA) nanoparticles (Pep-NP) may improve this. Here we studied the uptake of NP and the capacity of NP and Pep-NP to activate bone marrow dendr...

journal_title：European journal of pharmacology

authors： Kostadinova AI,Middelburg J,Ciulla M,Garssen J,Hennink WE,Knippels LMJ,van Nostrum CF,Willemsen LEM

更新日期：2018-01-05 00:00:00

abstract：:The disruption of redox state homeostasis, the overexpression of lipogenic transcription factors and enzymes, and the increase in lipogenic precursors induced by sweetened beverages are determinants of the development of nonalcoholic fatty liver disease. This study evaluated the action of nicotinamide (NAM) on the exp...

journal_title：European journal of pharmacology

authors： Mejía SÁ,Gutman LAB,Camarillo CO,Navarro RM,Becerra MCS,Santana LD,Cruz M,Pérez EH,Flores MD

更新日期：2018-01-05 00:00:00

abstract：:Acute lung injury (ALI) is a common severe clinical syndrome in intensive care unit. Inflammation has been reported to play a critical role in the development of ALI. Cordycepin, an active component isolated from Cordyceps militaris, has been reported to have anti-inflammatory effects. However, the anti-inflammatory e...

journal_title：European journal of pharmacology

authors： Lei J,Wei Y,Song P,Li Y,Zhang T,Feng Q,Xu G

更新日期：2018-01-05 00:00:00

abstract：:Atherosclerosis is a leading cause of death worldwide. It is a complex chronic inflammatory disease involving interactions between vascular, circulating and immune cells. B cells play an important role in chronic inflammation producing antibodies and regulating T and natural killer (NKT) cell activation. The role of B...

journal_title：European journal of pharmacology

authors： Nus M,Tsiantoulas D,Mallat Z

更新日期：2017-12-05 00:00:00

abstract：:Ischemia reperfusion (I/R) injury is a cellular damage in a hypoxic organ following the restoration of oxygen delivery. It may occur during organ transplantation, trauma and hepatectomies. Nitric oxide (NO) effects during hepatic I/R are complicated. The iNOS-derived NO has a deleterious effect, whereas eNOS-derived N...

journal_title：European journal of pharmacology

authors： Atef Y,El-Fayoumi HM,Abdel-Mottaleb Y,Mahmoud MF

更新日期：2017-11-15 00:00:00

abstract：:To investigate the detrusor fibrosis and urinary dysfunction in chronic prostatitis (CP), and to investigate whether resveratrol can improve the urinary dysfunction and the underlying molecular mechanism. After rat model of CP is established by subcutaneously injecting DPT vaccine, rats are treated with resveratrol. E...

journal_title：European journal of pharmacology

authors： He Y,Zeng H,Yu Y,Zhang J,Liu Q,Yang B

更新日期：2017-11-15 00:00:00

abstract：:Glycyrrhiza (the roots and rhizomes of licorice) has been used worldwide as both an herbal nutraceutical and herbal medicine. In addition, it is well known that Glycyrrhiza contains various compounds with biological effects, such as anti-viral, anti-inflammatory, immunoregulatory, anti-tumor and neuroprotective effect...

journal_title：European journal of pharmacology

authors： Nakatani Y,Kobe A,Kuriya M,Hiroki Y,Yahagi T,Sakakibara I,Matsuzaki K,Amano T

更新日期：2017-11-15 00:00:00

abstract：:This study aims to investigate the role of zolpidem in lithium-pilocarpine induced status epilepticus (SE) and probable mechanisms involved in seizure threshold alteration. In the present study, lithium chloride (127mg/kg) was administered 20h prior to pilocarpine (60mg/kg) to induce SE in adult male Wistar rats. Diff...

journal_title：European journal of pharmacology

authors： Eslami SM,Ghasemi M,Bahremand T,Momeny M,Gholami M,Sharifzadeh M,Dehpour AR

更新日期：2017-11-15 00:00:00

abstract：:Proof-of-pharmacology models to study compounds in healthy subjects offer multiple advantages. Simvastatin is known to induce mitochondrial dysfunction at least partly by depletion of co-enzyme Q10. The goal of this study was to evaluate a model of simvastatin-induced mitochondrial dysfunction in healthy subjects and ...

journal_title：European journal of pharmacology

authors： van Diemen MPJ,Berends CL,Akram N,Wezel J,Teeuwisse WM,Mik BG,Kan HE,Webb A,Beenakker JWM,Groeneveld GJ

更新日期：2017-11-15 00:00:00

abstract：:Cerebral ischemia/reperfusion (I/R) is a lethal and disabling disease. Studies have suggested that hyperglycemia is a risk factor for cerebral I/R. Baicalin is a natural bioactive flavonoid extracted from Scutellaria baicalensis Georgi with neuroprotective activity. In the present study, we investigated the effects of...

journal_title：European journal of pharmacology

authors： Li S,Sun X,Xu L,Sun R,Ma Z,Deng X,Liu B,Fu Q,Qu R,Ma S

更新日期：2017-11-15 00:00:00

abstract：:Opiate tolerance is a critical issue in pain management. Previous studies show that activation of Mas-related gene (Mrg) C receptor can modulate the development of morphine tolerance. This study was designed to investigate the underlying mechanism(s). Intrathecal (i.t.) administration of morphine (20µg) increased the ...

journal_title：European journal of pharmacology

authors： Zhang Y,Wang K,Lin M,Li Q,Hong Y

更新日期：2017-11-15 00:00:00

abstract：:Statins are well-known inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, which block the mevalonate pathway. The activity of statins not only decreases cholesterol levels but also ameliorates inflammation and modulates the immune system. In this study, we investigated the effects of simvastatin ...

journal_title：European journal of pharmacology

authors： Sahid MNA,Liu S,Kiyoi T,Maeyama K

更新日期：2017-11-05 00:00:00

abstract：:Exploring the importance of nanofibrous scaffold with traditionally important medicine as a wound dressing material prevents infection and aids in faster healing of wounds. In the present study, the Collagen (COL) from the marine fish skin was extracted and employed for coating the Poly(3-hydroxybutyric acid) (P)-Gela...

journal_title：European journal of pharmacology

authors： Ramanathan G,Muthukumar T,Tirichurapalli Sivagnanam U

更新日期：2017-11-05 00:00:00

abstract：:Microglia initially undergo rapid activation in response to injury and stressful stimuli, such as hypoxia. Oxidative stress and the inflammatory response play critical roles in hypoxic-ischemic brain injury. Carvedilol is a β-blocker used to treat high blood pressure and heart failure. In this study, we investigated w...

journal_title：European journal of pharmacology

authors： Gao X,Wu B,Fu Z,Zhang Z,Xu G

更新日期：2017-11-05 00:00:00

abstract：:Type 1 cannabinoid (CB1) and dopamine 2 long form (D2L) receptors can physically interact to form heteromers that display unique pharmacology in vitro compared to homomeric complexes. Co-expression of CB1 and D2L and co-application of CB1 and D2 agonists increases cAMP levels while administration of either agonist alo...

journal_title：European journal of pharmacology

authors： Bagher AM,Laprairie RB,Toguri JT,Kelly MEM,Denovan-Wright EM

更新日期：2017-10-15 00:00:00

abstract：:Type 2 diabetes mellitus (T2DM) is one of the risk factors for Parkinson's disease (PD). Insulin desensitisation has been observed in the brains of patients, which may promote neurodegeneration. Incretins are a family of growth factors that can re-sensitise insulin signalling. We have previously shown that mimetics of...

journal_title：European journal of pharmacology

authors： Yuan Z,Li D,Feng P,Xue G,Ji C,Li G,Hölscher C

更新日期：2017-10-05 00:00:00

abstract：:Flavonoids are polyphenols frequently consumed in the diet they have been suggested to exert a number of beneficial actions on human health, including anti-inflammatory activity. This study investigated the immunomodulatory effects of two flavonoids, Chrysin and Hesperetin. The effects of flavonoids on B and T cell pr...

journal_title：European journal of pharmacology

authors： Sassi A,Mokdad Bzéouich I,Mustapha N,Maatouk M,Ghedira K,Chekir-Ghedira L

更新日期：2017-10-05 00:00:00

abstract：:Pirfenidone recently received FDA approval as one of the first two drugs designed to treat idiopathic pulmonary fibrosis. While the clinical data continues to support the efficacy of pirfenidone, the specific molecular mechanism of action of this drug has not been fully defined. From a chemical perspective the compara...

journal_title：European journal of pharmacology

authors： Haak AJ,Girtman MA,Ali MF,Carmona EM,Limper AH,Tschumperlin DJ

更新日期：2017-09-15 00:00:00

abstract：:Oxidative stress and inflammation play key roles in the pathogenesis of Multiple sclerosis (MS). Different drugs have been used in the clinical practice, however, there is not a completely effective treatment. Due to its potential therapeutic action, medical ozone represents a promising approach for neurodegenerative ...

journal_title：European journal of pharmacology

authors： Delgado-Roche L,Riera-Romo M,Mesta F,Hernández-Matos Y,Barrios JM,Martínez-Sánchez G,Al-Dalaien SM

更新日期：2017-09-15 00:00:00

abstract：:Cisplatin (CDDP)-induced nephrotoxicity (CIN) is one of the most serious toxicities caused by this potent antitumor agent. It has been reported that Mg premedication attenuates CIN in clinical trials; however, the mechanism underlying its nephroprotection is not fully understood. Therefore, the aim of this study was t...

journal_title：European journal of pharmacology

authors： Saito Y,Okamoto K,Kobayashi M,Narumi K,Yamada T,Iseki K

更新日期：2017-09-15 00:00:00

abstract：:Human podocytes (hPC) are essential for maintaining normal kidney function and dysfunction or loss of hPC play a pivotal role in the manifestation and progression of chronic kidney diseases including diabetic nephropathy. Previously, α-Lipoic acid (α-LA), a licensed drug for treatment of diabetic neuropathy, was shown...

journal_title：European journal of pharmacology

authors： Leppert U,Gillespie A,Orphal M,Böhme K,Plum C,Nagorsen K,Berkholz J,Kreutz R,Eisenreich A

更新日期：2017-09-05 00:00:00

abstract：:In epithelial tumors, the epidermal growth factor receptor (EGFR) controls key signaling pathways responsible for growth, proliferation, migration, and survival of tumor cells. The epidermal growth factor receptor variant III (EGFRvIII) is the most common EGFR mutation that occurs in up to 30% of high-grade gliomas es...

journal_title：European journal of pharmacology

authors： Chistiakov DA,Chekhonin IV,Chekhonin VP

更新日期：2017-09-05 00:00:00

abstract：:Opioid antagonists, naloxone and naltrexone have long been used in clinical practice and research. In addition to their low selectivity, they easily pass through the blood-brain barrier. Quaternization of the amine group in these molecules, (e.g. methylnaltrexone) results in negligible CNS penetration. In addition, zw...

journal_title：European journal of pharmacology

authors： Zádor F,Király K,Váradi A,Balogh M,Fehér Á,Kocsis D,Erdei AI,Lackó E,Zádori ZS,Hosztafi S,Noszál B,Riba P,Benyhe S,Fürst S,Al-Khrasani M

更新日期：2017-08-15 00:00:00

abstract：:Pulmonary hypertension (PH) mainly results from excessive proliferation of pulmonary artery smooth muscle cells (PASMCs) and displays mitochondrial abnormalities such as mitochondrial fragmentation. Epigallocatechin-3-gallate (EGCG), an efficient antiproliferative compound in green tea, has recently been demonstrated ...

journal_title：European journal of pharmacology

authors： Zhu TT,Zhang WF,Luo P,He F,Ge XY,Zhang Z,Hu CP

更新日期：2017-08-15 00:00:00

abstract：:Due to the limited results achieved in the clinical treatment of heart failure, a new inotropic strategy of myosin motor activation has been developed. The lead molecule of myosin activator agents is omecamtiv mecarbil, which binds directly to the heavy chain of the cardiac β-myosin and enhances cardiac contractility ...

journal_title：European journal of pharmacology

authors： Nánási P Jr,Gaburjakova M,Gaburjakova J,Almássy J

更新日期：2017-08-15 00:00:00